Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi- derived COP-coated vesicles
نویسندگان
چکیده
The cycle of nucleotide exchange and hydrolysis by a small GTP-binding protein, ADP-ribosylation factor (ARF), helps to provide vectoriality to vesicle transport. Coat assembly is triggered when ARF binds GTP, initiating transport vesicle budding, and coat disassembly is triggered when ARF hydrolyzes GTP, allowing the uncoated vesicle to fuse.
منابع مشابه
Binding of coatomer to Golgi membranes requires ADP-ribosylation factor.
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ورودعنوان ژورنال:
- The Journal of Cell Biology
دوره 123 شماره
صفحات -
تاریخ انتشار 1993